Professor Christine Petit

Chair of the Scientific Advisory Board

Professor Christine Petit, M.D., Ph.D. presently serves concurrently as Professor at College de France, Chair of Genetics and Cellular Physiology, Professor at Institut Pasteur (Paris) and Head of the Laboratory of Genetics and Physiology of Hearing of the Pasteur Institute, affiliated to INSERM (UMRS 1120) and Sorbonne University (Paris). She is also Director of the French Hearing Institute, Paris, France. Among her most notable accomplishments are deciphering the genetic basis for human deafness, elucidating key molecular machineries for sound reception and encoding, and uncovering pathogenic processes for a large variety of hearing deficits. Based on these findings, she is now developing curative therapies for deafness. She has been the recipient of numerous prestigious awards for her scientific contributions, such as the Kavli Prize in Neuroscience, the ARO Lifetime Achievement Award of Merit (USA), the International Brain Prize from Grete Lundbeck Foundation, The Hughes Knowles Prize (USA), the Louis-Jeantet for Medicine Prize for her outstanding contribution to the understanding of the auditory science (Europe), the l’Oréal Unesco Award recognizing outstanding Women in Sciences (Europe) and the Grand Prize from the INSERM (France). She is a member of the French and American Sciences Academies and the American Medical Academy.

christine petit

Professor Alain Fischer

Pr Alain Fischer studied medicine, with a specialization in pediatrics and immunology at the Université of Paris. After completing a postdoctoral fellowship at the University College London, he started independent research in an Inserm unit at the Necker Hospital in Paris. From 2009 to 2016, he was the director of the Institute for Genetic Diseases (Imagine) at Necker University Hospital. Dr Fischer also served as a professor of pediatric immunology at the Université Paris Descartes. From 1996 to 2012, he has served as the director of the pediatric immunology department at the Necker Hospital. Dr Fischer is presently Professor at College de France. Dr Fischer's main research interests are gene therapy, primary immunodeficiency diseases, and the development of the lymphoid system. Dr Fischer received the Louis-Jeantet Prize for Medicine in 2001 and the Japan Prize 2015. He is a member of the French and US National Academies of Science and Medicine. 

alain fischer

Dr Robert Dow

Robert was formerly Chief Medical Officer at PPD Inc and has over 37 years’ experience in pharmaceutical and biotech industry. He has held a variety of senior executive positions at Syntex Corporation, Hoffman La Roche, and Cell Genesys Inc. He has substantial experience across a broad range of therapeutic areas in managing the transition of medicinal products from pre-clinical to clinical development and through Phase III. He has experience in the fields of toxicology, pharmacokinetics, clinical science, clinical operations, regulatory affairs, drug safety and pricing and reimbursement, also has substantial experience in regulatory interactions in the USA and Europe. Robert holds a BSc (Med.Sci), a MB ChB, a MRCP (UK) and is a Fellow of the Royal College of Physicians of Edinburgh and a Fellow of the Royal College of Pharmaceutical Physicians, UK. 

rob dow

Professor Paul Avan

Being both a physicist and a MD in biophysics, Paul Avan developed complementary skills to design original objective methods of exploration of the cochlea and auditory pathways. These methods have been validated on models of mutant mice with precisely defined molecular deficits that affect specific parts of their auditory system. The study of such models bridges the gap between two domains that shared few common knowledge two decades ago, audiology and molecular physiology. Once validated, the audiological tests developed by Paul Avan, currently head of the CERIAH (Center for Research and Innovation in Human Audiology at the Institut de l'Audition in Paris, France) have been applied to diagnosis in patients, and to the design of novel electrophysiological equipment detecting formerly inaccessible parameters, such as hydrostatic pressure of labyrinthine fluids. For this purpose, Paul Avan has contributed to the creation of a startup company, Echodia, which builds and sells CE-marked equipment.

paul avan

Dr Diane Lazard

Diane Lazard is an ENT surgeon, former 4 year-fellow at Hôpitaux de Paris and a PhD in Neurosciences (Ecole Normale Supérieure). She undertook several postdocs at the Bionics Institute, Melbourne, Australia, at Ecole Normale Supérieure, Paris, France, and at the Institute of Neurosciences, Montpellier, France. Her main basic research topic is cortical plasticity induced by deafness, and its links to cochlear implantation outcome. She also studied tinnitus and its central expression. Associate Principal Investigator of a team at the Hearing Institute in Paris, she is currently pursuing her work on deciphering language processing variability in deafness. She also combines surgical and teaching activities at the Institut Arthur Vernes, a non-profit surgical clinic in Paris.

 diane lazard

Dr Hernán López-Schier

Dr. Hernán López-Schier graduated with a PhD in genetics from the University of Cambridge (UK). He undertook postdoctoral work with A.J. Hudspeth at the Rockefeller University (USA). In 2007 he started his independent career as a Ramon y Cajal junior group leader at the Centre for Genomic Regulation in Barcelona (Spain). In 2012 he accepted an offer to become senior group leader and research unit director at the Helmholtz Center in Munich (Germany). In 2014 he was a visiting scholar at the Janelia Research Campus (USA), and in 2019 visiting professor at Harvard University (USA). He has supervised 20 students and postdoctoral fellows. He is the recipient of several accolades and grants, including an ERC Starting Grant (EU), and programme grants from the Human Frontier Science Program and the National Institutes of Health (USA). His group's research focuses on fundamental sensory biology and sensory dysfunction. His group was the first to visualise the regeneration of mechanosensory hair cells in their natural context.

hernan lopez schier




20200910 pipeline


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